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Admin27.06.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Conclusions: Defects in HR compiled under the term BRCAness are a common event in MPM.
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Admin20.06.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

PMID: 33122816 Free PMC article.
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Admin28.06.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Furthermore, we aimed to find possible correlations between response and gene expression patterns associated with BRCAness phenotype.
Admin27.08.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

4 Department of Pathology, Helios Klinikum Emil von Behring, Berlin, Germany.
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Admin28.07.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

It is suggested that loss-of-function mutation of BAP1 also results in BRCAness phenotype.
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Admin24.08.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Therefore, 91 clinical MPM samples were digitally screened for gene expression patterns of HR members.
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Admin04.08.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

a: BAP1 was rarely expressed in the cell line that showed response to olaparib treatment NCI H2452 , while it was expressed in other cell lines that showed no response 160 to 250 counts.
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Admin16.07.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Montanaro F, Rosato R, Gangemi M, Roberti S, Ricceri F, Merler E, et al.
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Admin13.08.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

1 Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
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Admin22.06.2021

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

The reasons for the rather poor efficacy of chemotherapeutic treatment are largely unknown.
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